The diversity of mycolactone-producing mycobacteria

Mycolactone-producing mycobacteria (MPM) form an intriguing group of environmental opportunistic pathogens of mammals and human patients in whom they cause cutaneous and subcutaneous ulcers known as “Buruli ulcer” when they occur in humans. We reviewed whole genome sequence data and ecological and p...

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Bibliographic Details
Published inMicrobial pathogenesis Vol. 149; p. 104362
Main Authors Hammoudi, N., Saad, J., Drancourt, M.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.12.2020
Subjects
Clones
Diversity
Mapping
Mycobacterium
Mycobacterium marinum
Mycobacterium ulcerans
Taxonomy
Mycobacterium
Mycobacterium ulcerans
Mycobacterium marinum
Taxonomy
Diversity
Mapping
Clones
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Summary:Mycolactone-producing mycobacteria (MPM) form an intriguing group of environmental opportunistic pathogens of mammals and human patients in whom they cause cutaneous and subcutaneous ulcers known as “Buruli ulcer” when they occur in humans. We reviewed whole genome sequence data and ecological and phenotypic characteristics from 44 MPMs and closely related Mycobacterium marinum. This analysis indicated that all the 24 M. marinum isolates were delineated into seven taxa and our comprehensive, polyphasic taxonomic approach led to the proposal of delineating M. marinum genomospecies, 01–07. Likewise, 20 MPMs isolates were delineated into seven additional M. ulcerans genomospecies, 01–07. A taxonomic card explaining the ecology, hosts of isolation and the plasmid harboured is provided for each taxon.
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ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2020.104362