Jasmine rice panicle: A safe and efficient natural ingredient for skin aging treatments

• Published in: Journal of ethnopharmacology Vol. 193; pp. 607 - 616
• Main Authors: Kanlayavattanakul, Mayuree, Lourith, Nattaya, Chaikul, Puxvadee
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 04.12.2016
• Subjects: Adult; Animals; Antioxidants - isolation & purification; Antioxidants - pharmacology; Antioxidants - toxicity; Cell Line, Tumor; Cell Survival - drug effects; Cellular activities; Clinical trials; Double-Blind Method; Drug Stability; Female; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibroblasts - pathology; Healthy Volunteers; Humans; In vitro activities; Inflorescence - chemistry; Jasmine rice panicle; Melanins - metabolism; Melanocytes - drug effects; Melanocytes - metabolism; Melanocytes - pathology; Mice; Middle Aged; Oryza - chemistry; Patch Tests; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Extracts - toxicity; Skin - drug effects; Skin - pathology; Skin aging; Skin Aging - drug effects; Skin Irritancy Tests; Young Adult; Clinical trials; Skin aging; In vitro activities; Jasmine rice panicle; Cellular activities
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2016.10.013

While rice is one of the most important global staple food sources its extracts have found many uses as the bases of herbal remedies. Rice extracts contain high levels of phenolic compounds which are known to be bioactive, some of which show cutaneous benefits and activity towards skin disorders. This study highlights an assessment of the cellular activity and clinical efficacy of rice panicle extract, providing necessary information relevant to the development of new cosmetic products. Jasmine rice panicle extract was standardized, and the level of phenolics present was determined. In vitro anti-aging, and extract activity towards melanogenesis was conducted in B16F10 melanoma cells, and antioxidant activity was assessed in human skin fibroblast cell cultures. Topical product creams containing the extract were developed, and skin irritation testing using a single application closed patch test method was done using 20 Thai volunteers. Randomized double-blind, placebo-controlled efficacy evaluation was undertaken in 24 volunteers over an 84d period, with the results monitored by Corneometer® CM 825, Cutometer® MPA 580, Mexameter® MX 18 and Visioscan® VC 98. Jasmine rice panicle extract was shown to have a high content of p-coumaric, ferulic and caffeic acids, and was not cytotoxic to the cell lines used in this study. Cells treated with extract suppressed melanogenesis via tyrosinase and TRP-2 inhibitory effects, which protect the cell from oxidative stress at doses of 0.1mg/ml or lower. The jasmine rice panicle preparations (0.1–0.2%) were safe (MII=0), and significantly (p<0.05) increased skin hydration levels relative to baseline. Skin lightening, and anti-wrinkle effects related to skin firmness and smoothness were observed, in addition to a reduction in skin wrinkling. Improvements in skin biophysics of both 0.1% and 0.2% extracts were showed to be comparable (p>0.05). Jasmine rice panicle extract having high levels of phenolics shows cutaneous benefits as the basis for skin aging treatments, as indicated through in vitro cytotoxicity assessments and skin testing in human subjects. [Display omitted]