Deferoxamine Attenuates White Matter Injury in a Piglet Intracerebral Hemorrhage Model

• Published in: Stroke (1970) Vol. 45; no. 1; pp. 290 - 292
• Main Authors: QING XIE, YUXIANG GU, YA HUA, WENQUAN LIU, KEEP, Richard F, GUOHUA XI
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.01.2014
• Subjects: Animals; Biological and medical sciences; Blotting, Western; Body Water - chemistry; Brain - pathology; Brain Chemistry - drug effects; Brain Edema - drug therapy; Brain Edema - pathology; Cerebral Hemorrhage - drug therapy; Cerebral Hemorrhage - metabolism; Cerebral Hemorrhage - pathology; Deferoxamine - therapeutic use; Freezing; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Iron - metabolism; Male; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Neuropharmacology; Neuroprotective agent; Pharmacology. Drug treatments; Receptor-Interacting Protein Serine-Threonine Kinases - metabolism; Siderophores - therapeutic use; Swine; Tumor Necrosis Factor-alpha - metabolism; Vascular diseases and vascular malformations of the nervous system; brain edema; Stroke; Nervous system diseases; receptor-interacting protein serine-threonine kinase 1; Enzyme; Transferases; Non-specific serine/threonine protein kinase; Cardiovascular disease; White matter; Cerebral disorder; Deferoxamine; Necrosis; Vascular disease; tumor necrosis factor-alpha; Cerebral hemorrhage; Central nervous system disease; Chelating agent; Tumor; Antidote; Cerebral edema; Cerebrovascular disease; deferoxamine; cerebral hemorrhage
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/STROKEAHA.113.003033

Deferoxamine reduces neuronal death in a piglet model of intracerebral hemorrhage (ICH). This study examined the effect of deferoxamine on perihematomal white matter edema in piglets. ICH was induced by an injection of autologous blood into the right frontal lobe of piglets. In the first part of study, the time course of edema formation was determined. In the second part, the effects of deferoxamine on ICH-induced white matter edema, tumor necrosis factor α, and receptor-interacting protein kinase 1 were examined. ICH resulted in marked brain edema and increased tumor necrosis factor α and receptor-interacting protein kinase 1 levels in white matter. Systemic treatment with deferoxamine markedly reduced white matter tumor necrosis factor α and receptor-interacting protein kinase 1 levels and attenuated white matter edema after ICH. Deferoxamine reduces white matter edema, tumor necrosis factor α, and receptor-interacting protein kinase 1 levels after ICH in piglets, suggesting deferoxamine is a potential effective therapeutic agent for patients with ICH.