Phylloquinone in plasma from elderly and young adults: factors influencing its concentration

• Published in: The American journal of clinical nutrition Vol. 50; no. 1; pp. 100 - 108
• Main Authors: Sadowski, J A, Hood, S J, Dallal, G E, Garry, P J
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.07.1989; American Society for Clinical Nutrition
• Subjects: Adult; ADULTE; ADULTOS; Aged; Aged, 80 and over; Aging; ANALISIS ESTADISTICO; ANALYSE STATISTIQUE; Analytical, structural and metabolic biochemistry; Biological and medical sciences; CHOLESTEROL; Coenzymes, vitamins; COLESTEROL; Fasting; Female; Fundamental and applied biological sciences. Psychology; Humans; LIPOPROTEINAS; LIPOPROTEINE; Male; Middle Aged; Nutritional Status; Other biological molecules; PLASMA SANGUIN; PLASMA SANGUINEO; RETINOL; Sex Factors; TOCOFEROLES; TOCOPHEROL; TRIGLICERIDOS; TRIGLYCERIDE; Triglycerides - blood; Vitamin A - blood; Vitamin E - blood; Vitamin K - blood; Vitamin K 1 - blood; VITAMINA K; VITAMINE K; Human; Statistical analysis; Nutrition; Vitamin; HPLC chromatography; Lipids; α-Tocopherol; Triglyceride; Blood; Blood plasma; Young adult; Phylloquinone; Woman; Age; Comparative study; Vitamin K
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/50.1.100

Fasting plasma phylloquinone concentrations were determined by reverse-phase high-performance liquid chromatography in a population of young (n = 131) and elderly (n = 195) human subjects. The distribution of values was non-Gaussian but was converted to Gaussian form after a logarithmic transformation of the data. The normal range derived from the lognormal distribution was 0.29–2.64 nmol/L (geometric means = 0.87 nmol/L, median = 0.86 nmol/L). Young females had significantly decreased plasma phylloquinone concentrations when compared with the elderly females whereas concentrations in young males were slightly higher than those in elderly males. A regression model was constructed and revealed that plasma phylloquinone concentrations were positively correlated with plasma triglycerides and alpha-tocopherol. Although the elderly subjects (means = 1.05 nmol/L) had higher levels of phylloquinone than the young subjects (0.94 nmol/L), when the concentration of phylloquinone in plasma is expressed as nanomoles phylloquinone per millimole of triglyceride, the elderly subjects (0.62 x 10(-6) showed decreased levels for phylloquinone compared with the young subjects (0.82 x 10(-6) (p less than 0.001).