Anti-Helicobacter, Antitubercular and Cytotoxic Activities of Scalaranes from the Red Sea Sponge Hyrtios erectus

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 4; p. 978
• Main Authors: Alahdal, Abdulrahman M, Asfour, Hani Z, Ahmed, Safwat A, Noor, Ahmad O, Al-Abd, Ahmed M, Elfaky, Mahmoud A, Elhady, Sameh S
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.04.2018; MDPI
• Subjects: 12-O-deacetyl-12,19-di-epi-scalarin; antitubercular; Antitubercular Agents - pharmacology; Biological activity; Cell lines; cytotoxic; Cytotoxicity; Drug Screening Assays, Antitumor - methods; Helicobacter - drug effects; Helicobacter pylori; Hep G2 Cells; Humans; Hyrtios; Hyrtios erectus; Magnetic Resonance Spectroscopy; Mass spectroscopy; Molecular Structure; NMR; Nuclear magnetic resonance; scalarane sesterterpenoids; sponges (Porifera); Red Sea; scalarane sesterterpenoids; 12-O-deacetyl-12,19-di-epi-scalarin; Helicobacter pylori; antitubercular; sponges (Porifera); Hyrtios erectus; cytotoxic
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules23040978

The Red Sea specimen of the marine sponge (order Dictyoceratida) was found to contain scalarane-type sesterterpenes. 12- -deacetyl-12,19-di- -scalarin ( ), a new scalarane sesterterpenoid, along with fourteen previously-reported scalarane-type sesterterpenes ( ⁻ and ) have been isolated. The chemical structures of the isolated compounds were elucidated on the basis of detailed 1D and 2D NMR spectral data and mass spectroscopy, as well as by comparison with reported data. The anti- , antitubercular and cytotoxic activities of all fifteen compounds were evaluated to reveal the potency of Compounds , , , , , and . Amongst these, Compounds , , , and displayed a promising bioactivity profile, possessing potent activities in the antitubercular and anti- bioassay. Compounds and showed the most promising cytotoxic profile, while Compounds and showed a moderate cytotoxic profile against MCF-7, HCT-116 and HepG2 cell lines.