Association Between Hemodynamic Profile, Physical Capacity and Quality of Life in Pulmonary Hypertension

• Published in: Arquivos brasileiros de cardiologia Vol. 104; no. 5; pp. 387 - 393
• Main Authors: Torres, Diego de Faria Magalhães, Zin, Walter Araujo, Lopes, Agnaldo José, Vigário, Patrícia dos Santos, Garcia, Marcelo Iorio, Waetge, Daniel, Bandeira, Marcelo Luiz da Silva, Bessa, Luiz Gustavo Pignataro, Guimarães, Fernando Silva
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Cardiologia 01.05.2015; Sociedade Brasileira de Cardiologia - SBC; Sociedade Brasileira de Cardiologia (SBC)
• Subjects: Adult; Blood Pressure - physiology; CARDIAC & CARDIOVASCULAR SYSTEMS; Cross-Sectional Studies; Doença Cardiopulmonar; Exercise - physiology; Exercise Test - methods; Exercise Tolerance - physiology; Female; Hemodinâmica / fisiopatologia; Hemodynamics - physiology; Hipertensão Pulmonar; Humans; Hypertension, Pulmonary - physiopathology; Male; Middle Aged; Original; Oxygen Consumption; Prognosis; Qualidade de Vida; Quality of Life; Reference Values; Respiratory Function Tests; Statistics, Nonparametric; Surveys and Questionnaires; Time Factors; Walking - physiology; Qualidade de Vida; Doença Cardiopulmonar; Quality of Life; Hipertensão Pulmonar; Hypertension, Pulmonary; Hemodinâmica / fisiopatologia; Hemodynamics / physiopathology; Pulmonary Heart Disease
• ISSN: 0066-782X; 1678-4170; 1678-4170
• DOI: 10.5935/abc.20150012

No studies have described and evaluated the association between hemodynamics, physical limitations and quality of life in patients with pulmonary hypertension (PH) without concomitant cardiovascular or respiratory disease. To describe the hemodynamic profile, quality of life and physical capacity of patients with PH from groups I and IV and to study the association between these outcomes. Cross-sectional study of patients with PH from clinical groups I and IV and functional classes II and III undergoing the following assessments: hemodynamics, exercise tolerance and quality of life. This study assessed 20 patients with a mean age of 46.8 ± 14.3 years. They had pulmonary capillary wedge pressure of 10.5 ± 3.7 mm Hg, 6-minute walk distance test (6MWDT) of 463 ± 78 m, oxygen consumption at peak exercise of 12.9 ± 4.3 mLO2.kg-1.min-1 and scores of quality of life domains < 60%. There were associations between cardiac index (CI) and ventilatory equivalent for CO2 (r=-0.59, p <0.01), IC and ventilatory equivalent for oxygen (r=-0.49, p<0.05), right atrial pressure (RAP) and 'general health perception' domain (r=-0.61, p<0.01), RAP and 6MWTD (r=-0.49, p<0.05), pulmonary vascular resistance (PVR) and 'physical functioning' domain (r=-0.56, p<0.01), PVR and 6MWTD (r=-0.49, p<0.05) and PVR index and physical capacity (r=-0.51, p<0.01). Patients with PH from groups I and IV and functional classes II and III exhibit a reduction in physical capacity and in the physical and mental components of quality of life. The hemodynamic variables CI, diastolic pulmonary arterial pressure, RAP, PVR and PVR index are associated with exercise tolerance and quality of life domains.