Altered expression of the DISC1 gene in peripheral blood of patients with schizophrenia

• Published in: BMC medical genetics Vol. 21; no. 1; pp. 1 - 6
• Main Authors: Fu, Xiaoqian, Zhang, Guofu, Liu, Yansong, Zhang, Ling, Zhang, Fuquan, Zhou, Conghua
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 02.10.2020; BioMed Central; BMC
• Subjects: Antipsychotics; Aripiprazole; Brain research; Care and treatment; Comparative analysis; DISC1; Disc1 protein; Dopamine; Drug therapy; Gene expression; Genes; Genetic aspects; Genetic research; Homeostasis; Leukocytes (mononuclear); Medical research; Mental disorders; Neurons; Patients; Peripheral blood mononuclear cells; Psychotropic drugs; Schizophrenia; Statistical analysis; Synaptogenesis

Schizophrenia is a severe, heritable, and refractory psychiatric disorder. Several studies have shown that the disrupted in schizophrenia 1 (DISC1) gene is closely associated with schizophrenia by its role in neuronal morphology, synaptic function, brain development, and dopamine homeostasis etc. Th...