Altered expression of the DISC1 gene in peripheral blood of patients with schizophrenia

Schizophrenia is a severe, heritable, and refractory psychiatric disorder. Several studies have shown that the disrupted in schizophrenia 1 (DISC1) gene is closely associated with schizophrenia by its role in neuronal morphology, synaptic function, brain development, and dopamine homeostasis etc. Th...

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Published inBMC medical genetics Vol. 21; no. 1; pp. 1 - 6
Main Authors Fu, Xiaoqian, Zhang, Guofu, Liu, Yansong, Zhang, Ling, Zhang, Fuquan, Zhou, Conghua
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 02.10.2020
BioMed Central
BMC
Subjects
Antipsychotics
Aripiprazole
Brain research
Care and treatment
Comparative analysis
DISC1
Disc1 protein
Dopamine
Drug therapy
Gene expression
Genes
Genetic aspects
Genetic research
Homeostasis
Leukocytes (mononuclear)
Medical research
Mental disorders
Neurons
Patients
Peripheral blood mononuclear cells
Psychotropic drugs
Schizophrenia
Statistical analysis
Synaptogenesis
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Summary:Schizophrenia is a severe, heritable, and refractory psychiatric disorder. Several studies have shown that the disrupted in schizophrenia 1 (DISC1) gene is closely associated with schizophrenia by its role in neuronal morphology, synaptic function, brain development, and dopamine homeostasis etc. This study intended to investigate the expression levels of DISC1 gene in schizophrenia patients compared with healthy controls, and the expression variation of DISC1 gene before and after antipsychotic treatment in schizophrenia patients. In this study, we compared DISC1 expression levels in blood of 48 healthy controls, and 32 schizophrenia patients before and after 12 weeks of antipsychotic treatment using real-time quantitative PCR (RT-qPCR) analysis. The expression levels of DISC1 gene in peripheral blood mononuclear cells of schizophrenia patients before antipsychotic treatment were higher than those in healthy controls (P < 0.01); whereas after antipsychotic treatment, the expression levels of DISC1 gene in peripheral blood mononuclear cells of schizophrenia patients still remained increased (P < 0.01). Our study provided further support for the involvement of DISC1 in the development of schizophrenia.
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ISSN:1471-2350
1471-2350
DOI:10.1186/s12881-020-01132-9