Core-Shell Upconversion Nanoparticle@Metal-Organic Framework Nanoprobes for Luminescent/Magnetic Dual-Mode Targeted Imaging

• Published in: Advanced materials (Weinheim) Vol. 27; no. 27; pp. 4075 - 4080
• Main Authors: Li, Yantao, Tang, Jinglong, He, Liangcan, Liu, Yong, Liu, Yaling, Chen, Chunying, Tang, Zhiyong
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 15.07.2015
• Subjects: Animals; biocompatibility; Biocompatible Materials - chemical synthesis; Biocompatible Materials - chemistry; Cell Line, Tumor; Cell Survival; Contrast Media - chemical synthesis; Contrast Media - chemistry; core-shell nanostructures; dual-mode targeted imaging; Humans; Luminescence; Luminescent Measurements - instrumentation; Luminescent Measurements - methods; Magnetic Resonance Imaging - instrumentation; Magnetic Resonance Imaging - methods; Magnetite Nanoparticles - chemistry; Mice, Inbred BALB C; Mice, Nude; Microscopy, Confocal; Microscopy, Electron, Transmission; Neoplasm Transplantation; Polyethylene Glycols - chemistry; Spectrum Analysis; surface modification; Water - chemistry; X-Ray Diffraction; core-shell nanostructures; dual-mode targeted imaging; biocompatibility; surface modification
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.201501779

Core–shell upconversion nanoparticle@metal–organic framework (UCNP@MOF) nanostructures are constructed by coating hexagonal NaYF4:Yb,Er nanoparticle (NP) cores with amino‐functionalized iron carboxylate MOF shells. These nanostructures combine the near‐infrared optical property of the UCNP cores and the T2‐magnetic response (MR) imaging property of the MOF shells. After surface modification, the core–shell nanostructures are demonstrated as high‐resolution nanoprobes for targeted luminescence/MR imaging both in vitro and in vivo.