Detecting Awareness in the Vegetative State

• Published in: Annals of the New York Academy of Sciences Vol. 1129; no. 1; pp. 130 - 138
• Main Authors: Owen, Adrian M., Coleman, Martin R.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.05.2008
• Subjects: activation; Awareness - physiology; Cognition - physiology; cognitive function; fMRI scan; Humans; Magnetic Resonance Imaging; Persistent Vegetative State - physiopathology; Speech - physiology; vegetative state
• ISSN: 0077-8923; 1749-6632
• DOI: 10.1196/annals.1417.018

The assessment of residual brain function in the vegetative state, is extremely difficult and depends frequently on subjective interpretations of observed spontaneous and volitional behaviors. For those patients who retain peripheral motor function, rigorous behavioral assessment supported by structural imaging and electrophysiology is usually sufficient to establish a patient's level of wakefulness and awareness. However, it is becoming increasingly apparent that, in some patients, damage to the peripheral motor system may prevent overt responses to command, even though the cognitive ability to perceive and understand such commands may remain intact. Advances in functional neuroimaging suggest a novel solution to this problem; in several recent cases, so‐called “activation” studies have been used to identify residual cognitive function and even conscious awareness in patients who are assumed to be vegetative, yet retain cognitive abilities that have evaded detection using standard clinical methods.