Stimulatory effect of an LHRH-agonist on testicular blood flow in hypophysectomized rats

The effect of an LHRH-agonist (A) on testicular blood flow and plasma testosterone levels was studied in adult hypophysectomized rats. Subcutaneous injection of 1 microgram LHRH-agonist 2 or 4 h prior to experiment induced an increase in testicular blood flow. ( 21.1 +/- 2.8 ml/100 g X min; LHRH-A +...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of andrology Vol. 7; no. 3; p. 236
Main Authors Damber, J E, Bergh, A, Daehlin, L
Format Journal Article
LanguageEnglish
Published England 01.06.1984
Subjects
Animals
Epididymis - blood supply
Gonadotropin-Releasing Hormone - analogs & derivatives
Gonadotropin-Releasing Hormone - pharmacology
Hypophysectomy
Male
Rats
Regional Blood Flow - drug effects
Testis - blood supply
Testosterone - blood
Online AccessGet more information

Cover

More Information
Summary:The effect of an LHRH-agonist (A) on testicular blood flow and plasma testosterone levels was studied in adult hypophysectomized rats. Subcutaneous injection of 1 microgram LHRH-agonist 2 or 4 h prior to experiment induced an increase in testicular blood flow. ( 21.1 +/- 2.8 ml/100 g X min; LHRH-A + 2 h: 28.9 +/- 3.3 ml/100 g X min; LHRH-A + 4 h: 32.4 +/- 4.1 ml/100 g X min P less than 0.05; all mean +/- SEM). There was also a significant increase in plasma testosterone levels at 2 h (P less than 0.01) and 4 h (P less than 0.01) after treatment with the LHRH-agonist, with a peak at 2 h.
ISSN:0105-6263
DOI:10.1111/j.1365-2605.1984.tb00780.x