Impulsive and compulsive behaviors in Parkinson's disease

• Published in: Movement disorders Vol. 24; no. 11; pp. 1561 - 1570
• Main Authors: Evans, Andrew H., Strafella, Antonio P., Weintraub, Daniel, Stacy, Mark
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.08.2009; Wiley
• Subjects: Antiparkinson Agents - adverse effects; Antiparkinson Agents - therapeutic use; Biological and medical sciences; Compulsive Behavior - chemically induced; Compulsive Behavior - epidemiology; Compulsive Behavior - physiopathology; Deep Brain Stimulation; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Susceptibility; Dopamine - physiology; Dopamine Agonists - adverse effects; Dopamine Agonists - therapeutic use; dopamine dysregulation syndrome; Female; Gambling; Humans; impulse control disorders; Impulsive Behavior - chemically induced; Impulsive Behavior - epidemiology; Impulsive Behavior - physiopathology; Limbic System - drug effects; Limbic System - physiopathology; Male; Medical sciences; mesolimbic; Neurology; Parkinson Disease - drug therapy; Parkinson Disease - psychology; Parkinson's disease; Prevalence; punding; punding, mesolimbic; Reward; Sexual Behavior - drug effects; Stereotyped Behavior - drug effects; ventral striatum; dopamine dysregulation syndrome; reward; Nervous system diseases; Dopamine; Impulse control disorder; Parkinson's disease; mesolimbic; ventral striatum; Parkinson disease; Catecholamine; Cerebral disorder; Behavioral disorder; Central nervous system disease; Neurotransmitter; impulse control disorders; punding; Degenerative disease; Behavior; Extrapyramidal syndrome

Antiparkinson therapy can be the primary cause of a range of nonmotor symptoms that include a set of complex disinhibitory psychomotor pathologies and are linked by their repetitive, reward or incentive‐based natures. These behaviors relate to aberrant or excessive dopamine receptor stimulation and...