Impulsive and compulsive behaviors in Parkinson's disease

• Published in: Movement disorders Vol. 24; no. 11; pp. 1561 - 1570
• Main Authors: Evans, Andrew H., Strafella, Antonio P., Weintraub, Daniel, Stacy, Mark
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.08.2009; Wiley
• Subjects: Antiparkinson Agents - adverse effects; Antiparkinson Agents - therapeutic use; Biological and medical sciences; Compulsive Behavior - chemically induced; Compulsive Behavior - epidemiology; Compulsive Behavior - physiopathology; Deep Brain Stimulation; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Susceptibility; Dopamine - physiology; Dopamine Agonists - adverse effects; Dopamine Agonists - therapeutic use; dopamine dysregulation syndrome; Female; Gambling; Humans; impulse control disorders; Impulsive Behavior - chemically induced; Impulsive Behavior - epidemiology; Impulsive Behavior - physiopathology; Limbic System - drug effects; Limbic System - physiopathology; Male; Medical sciences; mesolimbic; Neurology; Parkinson Disease - drug therapy; Parkinson Disease - psychology; Parkinson's disease; Prevalence; punding; punding, mesolimbic; Reward; Sexual Behavior - drug effects; Stereotyped Behavior - drug effects; ventral striatum; dopamine dysregulation syndrome; reward; Nervous system diseases; Dopamine; Impulse control disorder; Parkinson's disease; mesolimbic; ventral striatum; Parkinson disease; Catecholamine; Cerebral disorder; Behavioral disorder; Central nervous system disease; Neurotransmitter; impulse control disorders; punding; Degenerative disease; Behavior; Extrapyramidal syndrome
• ISSN: 0885-3185; 1531-8257
• DOI: 10.1002/mds.22505

Antiparkinson therapy can be the primary cause of a range of nonmotor symptoms that include a set of complex disinhibitory psychomotor pathologies and are linked by their repetitive, reward or incentive‐based natures. These behaviors relate to aberrant or excessive dopamine receptor stimulation and encompass impulse control disorders (ICDs), punding, and the dopamine dysregulation syndrome (DDS). Common ICDs include pathological gambling, hypersexuality, compulsive eating, and compulsive buying. This review focuses on the phenomenology, epidemiology, and methods to identify and rate these disorders. The management of dopaminergic drug‐related compulsive behaviors is discussed in the light of the current understanding of the neurobiological substrate of these disorders. © 2009 Movement Disorder Society