Levels of awakening salivary CgA in response to stress in healthy subjects

• Published in: Environmental health and preventive medicine Vol. 16; no. 3; pp. 155 - 157
• Main Authors: Den, Rei, Toda, Masahiro, Ohira, Masako, Morimoto, Kanehisa
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.05.2011; Komiyama Printing Co., Ltd; Springer Japan
• Subjects: Adult and adolescent clinical studies; Awakening; Biological and medical sciences; Biomarkers - analysis; Body fluids; Chromogranin A; Chromogranin A - analysis; Chromogranin A - physiology; Depression; Depressive Disorder - physiopathology; Environmental health; Humans; Japan; Male; Medical sciences; Mental depression; Mood disorders; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Regular; Saliva; Saliva - chemistry; Sleep; Stress; Stress, Psychological - diagnosis; Stress, Psychological - etiology; Stress, Psychological - physiopathology; Time Factors; Young Adult; Japan; Mood disorder; Human; Biological fluid; Chromogranin A; Healthy subject; Awakening; Depression; Saliva; Public health; Stress; Biological monitoring
• ISSN: 1342-078X; 1347-4715; 1347-4715
• DOI: 10.1007/s12199-010-0179-5

To determine the changes in salivary chromogranin A (CgA) levels upon awakening in response to of stress by investigating the relationship between salivary CgA levels and the stress response as assessed by GHQ-28 tests. The study cohort comprised 40 healthy male university students (age range 19-22 years). Salivary CgA levels were measured at 7:00 a.m. (awakening) and at 7:30, 8:00, and 8:30 a.m. (after awakening). The salivary CgA level was 0.91 ± 0.20 and 0.42 ± 0.1 pmol/ml at 7:00 a.m. in students scoring low (n = 26) and high (n = 14), respectively, on the "severe depression" subscale. This difference in salivary CgA levels at 7:00 between high and low scorers was statistically significant (p < 0.05). Our findings indicate that depression may influence secretions of salivary CgA via chronic stress-related attenuation of the sympathetic-adrenomedullary system activity.