The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease

• Published in: Movement disorders Vol. 24; no. 11; pp. 1641 - 1649
• Main Authors: Barone, Paolo, Antonini, Angelo, Colosimo, Carlo, Marconi, Roberto, Morgante, Letterio, Avarello, Tania P., Bottacchi, Eugenio, Cannas, Antonino, Ceravolo, Gabriella, Ceravolo, Roberto, Cicarelli, Giulio, Gaglio, Roberto M., Giglia, Rosa M., Iemolo, Francesco, Manfredi, Michela, Meco, Giuseppe, Nicoletti, Alessandra, Pederzoli, Massimo, Petrone, Alfredo, Pisani, Antonio, Pontieri, Francesco E., Quatrale, Rocco, Ramat, Silvia, Scala, Rosanna, Volpe, Giuseppe, Zappulla, Salvatore, Bentivoglio, Anna Rita, Stocchi, Fabrizio, Trianni, Giorgio, Dotto, Paolo Del
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.08.2009; Wiley
• Subjects: Aged; Antiparkinson Agents - therapeutic use; Anxiety - epidemiology; Anxiety - etiology; Anxiety - psychology; Biological and medical sciences; cognition; Cognition Disorders - epidemiology; Cognition Disorders - etiology; Cognition Disorders - psychology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Depression - epidemiology; Depression - etiology; Depression - psychology; Fatigue - epidemiology; Fatigue - etiology; Fatigue - psychology; Female; Gastrointestinal Diseases - epidemiology; Gastrointestinal Diseases - etiology; Gastrointestinal Diseases - psychology; Humans; Italy - epidemiology; Male; Medical sciences; Middle Aged; Neurology; nonmotor symptoms; Olfaction Disorders - epidemiology; Olfaction Disorders - etiology; Olfaction Disorders - psychology; Pain - epidemiology; Pain - etiology; Pain - psychology; Parkinson Disease - complications; Parkinson Disease - drug therapy; Parkinson Disease - psychology; Parkinson's disease; psychiatric symptoms; Quality of Life; Sleep Disorders, Intrinsic - epidemiology; Sleep Disorders, Intrinsic - etiology; Sleep Disorders, Intrinsic - psychology; Urination Disorders - epidemiology; Urination Disorders - etiology; Urination Disorders - psychology; Italy; Nervous system diseases; psychiatric symptoms; Parkinson's disease; nonmotor symptoms; Multicenter study; Parkinson disease; Cognition; Cerebral disorder; Quality of life; Central nervous system disease; Mental disorder; Degenerative disease; Extrapyramidal syndrome
• ISSN: 0885-3185; 1531-8257
• DOI: 10.1002/mds.22643

We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0–32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ‐39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales. © 2009 Movement Disorder Society