Angiotensin-converting enzyme and other peptidolytic enzymes in human semen and relations to its spermatologic parameters

Angiotensin-converting enzyme (ACE) and other enzymes of the renin-angiotensin system (RAS) occur in human semen in high activities. In contrast to bull ejaculates, not all zinc-dependent metallopeptidases are found to be in close correlation to the microscopically determined semen parameters; such...

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Bibliographic Details
Published inAndrologia Vol. 23; no. 2; p. 185
Main Authors Siems, W E, Heder, G, Hilse, H, Baeger, I, Engel, S, Jentzsch, K D
Format Journal Article
LanguageEnglish
Published Germany 01.03.1991
Subjects
Amino Acid Sequence
Humans
Infertility, Male - enzymology
Isoenzymes - metabolism
Male
Metalloendopeptidases - metabolism
Molecular Sequence Data
Peptidyl-Dipeptidase A - metabolism
Semen - enzymology
Sperm Count
Sperm Motility
Spermatozoa - cytology
Spermatozoa - enzymology
Spermatozoa - physiology
Zinc - pharmacology
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Summary:Angiotensin-converting enzyme (ACE) and other enzymes of the renin-angiotensin system (RAS) occur in human semen in high activities. In contrast to bull ejaculates, not all zinc-dependent metallopeptidases are found to be in close correlation to the microscopically determined semen parameters; such a relationship was established only partly for the ACE. On the other hand, the RAS-dependent spermatozoa-bound enzymes, inclusive ACE, uniformly show negative correlations to the spermatologic parameters of human semen. These results, for the first time, point to different functions of the sperm-cell-bound (testicular) and of the seminal plasma (pulmonary) ACE activities.
ISSN:0303-4569
DOI:10.1111/j.1439-0272.1991.tb02533.x