Metabolic pathways in T cell activation and lineage differentiation

Highlights • T cells adjust metabolic pathways during their life cycle according to their needs. • TCR activation is linked to metabolic reprogramming. • Cellular metabolic regulators shape T cell responses. • Manipulation of metabolic pathways can critically influence T cell activation and differen...

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Bibliographic Details
Published inSeminars in immunology Vol. 28; no. 5; pp. 514 - 524
Main Authors Almeida, Luís, Lochner, Matthias, Berod, Luciana, Sparwasser, Tim
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2016
Subjects
ACC
Allergy and Immunology
AMPK
Animals
Cell Differentiation
Energy Metabolism
Fatty acid metabolism
Fatty Acids - metabolism
Glycolysis
Humans
Immunologic Memory
Lymphocyte Activation - immunology
Metabolic Networks and Pathways
Metabolism
Mitochondria - metabolism
mTOR
Phenotype
Signal Transduction
T cells
T-Lymphocyte Subsets - cytology
T-Lymphocyte Subsets - physiology
ACC
Fatty acid metabolism
Glycolysis
mTOR
AMPK
T cells
Metabolism
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Summary:Highlights • T cells adjust metabolic pathways during their life cycle according to their needs. • TCR activation is linked to metabolic reprogramming. • Cellular metabolic regulators shape T cell responses. • Manipulation of metabolic pathways can critically influence T cell activation and differentiation. • Fatty acid metabolism controls the balance between an effector and a regulatory phenotype.
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ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2016.10.009