Deep Medullary Vein and MRI Markers Were Related to Cerebral Hemorrhage Subtypes

• Published in: Brain sciences Vol. 13; no. 9; p. 1315
• Main Authors: Wang, Dan, Xiang, Yayun, Peng, Yuling, Zeng, Peng, Zeng, Bang, Chai, Ying, Li, Yongmei
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2023; MDPI
• Subjects: Alcohol use; Amyloid; Blood pressure; Cardiovascular disease; Cerebral amyloid angiopathy; Cerebral hemispheres; cerebral small vessel disease; deep medullary vein; Diabetes; Diagnosis; Hemorrhage; Hypertension; intracerebral hemorrhage; Ischemia; Magnetic resonance imaging; Medical imaging; Medical records; Metabolic disorders; Mortality; Motor vehicles; MRI markers; Neuroimaging; registration; Risk factors; Scanners; Stroke; Substantia alba; Vascular diseases; Veins & arteries; China
• ISSN: 2076-3425; 2076-3425
• DOI: 10.3390/brainsci13091315

Background: To explore the performance of deep medullary vein (DMV) and magnetic resonance imaging (MRI) markers in different intracerebral hemorrhage (ICH) subtypes in patients with cerebral small vessel disease (CSVD). Methods: In total, 232 cases of CSVD with ICH were included in this study. The clinical and image data were retrospectively analyzed. Patients were divided into hypertensive arteriopathy (HTNA)-related ICH, cerebral amyloid angiopathy (CAA)-related ICH, and mixed ICH groups. The DMV score was determined in the cerebral hemisphere contralateral to the ICH. Results: The DMV score was different between the HTNA-related and mixed ICH groups (p < 0.01). The MRI markers and CSVD burden score were significant among the ICH groups (p < 0.05). Compared to mixed ICH, HTNA-related ICH diagnosis was associated with higher deep white matter hyperintensity (DWMH) (OR: 0.452, 95% CI: 0.253–0.809, p < 0.05) and high-degree perivascular space (PVS) (OR: 0.633, 95% CI: 0.416–0.963, p < 0.05), and CAA-related ICH diagnosis was associated with increased age (OR: 1.074; 95% CI: 1.028–1.122, p = 0.001). The DMV score correlated with cerebral microbleed (CMB), PVS, DWMH, periventricular white matter hyperintensity (PWMH), and CSVD burden score (p < 0.05) but not with lacuna (p > 0.05). Age was an independent risk factor for the severity of DMV score (OR: 1.052; 95% CI: 0.026–0.076, p < 0.001). Conclusion: DMV scores, CSVD markers, and CSVD burden scores were associated with different subtypes of ICH. In addition, DMV scores were associated with the severity of CSVD and CSVD markers.