Building SERS-active heteroassemblies for ultrasensitive Bisphenol A detection

• Published in: Biosensors & bioelectronics Vol. 81; pp. 138 - 142
• Main Authors: Feng, Jingjing, Xu, Liguang, Cui, Gang, Wu, Xiaoling, Ma, Wei, Kuang, Hua, Xu, Chuanlai
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 15.07.2016
• Subjects: Aptamers, Nucleotide - chemistry; Assembly; Bioelectricity; Biosensing Techniques - methods; Biotechnology; Bisphenol A; BPA detection; Drinking Water - analysis; Feasibility; Gold - chemistry; Gold nanoparticle-nanorod heteroassemblies; Inverse; Limit of Detection; Metal Nanoparticles - chemistry; Metal Nanoparticles - ultrastructure; Nanoparticles; Nanotubes - chemistry; Nanotubes - ultrastructure; Raman scattering; SERS; Spectrum Analysis, Raman - methods; Water Pollutants, Chemical - analysis; SERS; Gold nanoparticle-nanorod heteroassemblies; BPA detection
• ISSN: 0956-5663; 1873-4235
• DOI: 10.1016/j.bios.2016.02.055

Bisphenol A (BPA) usually exists in daily plastic products, as one of the most important endocrine disrupting chemicals. A sensitive surface-enhanced Raman scattering (SERS)-encoded aptasensor for the detection of BPA was developed, for the first time, based on gold nanoparticle-nanorod heteroassemblies. The high electromagnetic enhancement in narrow gaps between metal nanoparticles of these heteroassemblies led to marked Raman signals. It was found that the assembly degree and the corresponding SERS signals were in inverse correlation to the BPA concentrations over a wide linear range of 0.001–1ng/mL and the limit of detection was as low as 3.9pg/mL. Excellent recovery ranging from 91% to 95.3% was obtained to assess the feasibility of this method for real sample detection, indicating promising application for the detection of BPA. •A sensitive SERS encoded aptasensor for the detection of BPA was developed based on gold heteroassemblies.•It was found that the assembly degree and the corresponding SERS signals were in inverse proportion to the BPA concentrations.•The linear range was 0.001–1ng/mL and the limit of detection was as low as 3.9ng/mL.