A case of Marchiafava-Bignami disease: MRI findings on spin-echo and fluid attenuated inversion recovery (FLAIR) images

• Published in: European journal of radiology Vol. 34; no. 2; pp. 141 - 143
• Main Authors: Yamamoto, Takashi, Ashikaga, Ryuichiro, Araki, Yutaka, Nishimura, Yasumasa
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.05.2000; Elsevier Science
• Subjects: Alcoholism; Alcoholism - complications; Biological and medical sciences; Brain; Consciousness Disorders - diagnosis; Consciousness Disorders - etiology; Corpus callosum; Corpus Callosum - pathology; Diagnosis; Diseases; Fluid attenuated inversion recovery (FLAIR); Humans; Investigative techniques, diagnostic techniques (general aspects); Magnetic resonance imaging; Magnetic resonance imaging (MRI); Magnetic Resonance Imaging - methods; Male; Marchiafava-Bignami disease; Medical sciences; Middle Aged; Nervous system; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Marchiafava-Bignami disease; Magnetic resonance imaging (MRI); Alcoholism; Corpus callosum; Fluid attenuated inversion recovery (FLAIR); Case study; Human; Nervous system diseases; Central nervous system disease; Medical imagery; Spin echo; Diagnosis; Marchiafava Bignami disease; Nuclear magnetic resonance imaging; Cerebral disorder
• ISSN: 0720-048X; 1872-7727
• DOI: 10.1016/S0720-048X(99)00125-4

Marchiafava-Bignami disease (MBD) was diagnosed in a 56-year-old man. Spin-echo (SE) magnetic resonance imaging (MRI) at the acute phase showed normal signal areas in the central layer of the corpus callosum (CC), although the intensity of these areas revealed abnormal hyperintensity on fluid attenuated inversion recovery (FLAIR). On follow-up SE MRI at the late phase, the central layer of the CC showed fluid-like intensity. On FLAIR MRI, the lesions of the CC turned into hypointense cores surrounded by hyperintense rims indicating central necrosis and peripheral demyelination. Degenerative changes of the CC in MBD were clearly demonstrated by FLAIR MRI.