Multisystem Toxicity in Cancer: Lessons from NASA’s Countermeasures Program
Astronauts and cancer patients are subject to similar multisystem physiological toxicities. Over the past sixty years, NASA developed a state-of-the-art countermeasures program (CMP) to characterize and mitigate the physiological consequences of spaceflight. Here, we propose a NASA-modeled CMP to el...
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| Published in | Cell Vol. 179; no. 5; pp. 1003 - 1009 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Inc
14.11.2019
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| ISSN | 0092-8674 1097-4172 1097-4172 |
| DOI | 10.1016/j.cell.2019.10.024 |
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| Abstract | Astronauts and cancer patients are subject to similar multisystem physiological toxicities. Over the past sixty years, NASA developed a state-of-the-art countermeasures program (CMP) to characterize and mitigate the physiological consequences of spaceflight. Here, we propose a NASA-modeled CMP to elucidate and abrogate physiological toxicities in patients with cancer.
Astronauts and cancer patients are subject to similar multisystem physiological toxicities. Over the past sixty years, NASA developed a state-of-the-art countermeasures program (CMP) to characterize and mitigate the physiological consequences of spaceflight. Here, we propose a NASA-modeled CMP to elucidate and abrogate physiological toxicities in patients with cancer. |
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| AbstractList | Astronauts and cancer patients are subject to similar multisystem physiological toxicities. Over the past sixty years, NASA developed a state-of-the-art countermeasures program (CMP) to characterize and mitigate the physiological consequences of spaceflight. Here, we propose a NASA-modeled CMP to elucidate and abrogate physiological toxicities in patients with cancer. Astronauts and cancer patients are subject to similar multisystem physiological toxicities. Over the past sixty years, NASA developed a state-of-the-art countermeasures program (CMP) to characterize and mitigate the physiological consequences of spaceflight. Here, we propose a NASA-modeled CMP to elucidate and abrogate physiological toxicities in patients with cancer.Astronauts and cancer patients are subject to similar multisystem physiological toxicities. Over the past sixty years, NASA developed a state-of-the-art countermeasures program (CMP) to characterize and mitigate the physiological consequences of spaceflight. Here, we propose a NASA-modeled CMP to elucidate and abrogate physiological toxicities in patients with cancer. Astronauts and cancer patients are subject to similar multisystem physiological toxicities. Over the past sixty years, NASA developed a state-of-the-art countermeasures program (CMP) to characterize and mitigate the physiological consequences of spaceflight. Here, we propose a NASA-modeled CMP to elucidate and abrogate physiological toxicities in patients with cancer. Astronauts and cancer patients are subject to similar multisystem physiological toxicities. Over the past sixty years, NASA developed a state-of-the-art countermeasures program (CMP) to characterize and mitigate the physiological consequences of spaceflight. Here, we propose a NASA-modeled CMP to elucidate and abrogate physiological toxicities in patients with cancer. |
| Author | Charles, John B. Jones, Lee W. Dolan, Lianne B. Scott, Jessica M. Norton, Larry |
| AuthorAffiliation | 4 NASA Johnson Space Center, Houston, TX, USA 1 Memorial Sloan Kettering Cancer Center, New York, NY, USA 3 Princess Margaret Cancer Centre, Toronto, ON, Canada 2 Weill Cornell Medical College, New York, NY, USA |
| AuthorAffiliation_xml | – name: 4 NASA Johnson Space Center, Houston, TX, USA – name: 3 Princess Margaret Cancer Centre, Toronto, ON, Canada – name: 1 Memorial Sloan Kettering Cancer Center, New York, NY, USA – name: 2 Weill Cornell Medical College, New York, NY, USA |
| Author_xml | – sequence: 1 givenname: Jessica M. surname: Scott fullname: Scott, Jessica M. email: scottj1@mskcc.org organization: Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 2 givenname: Lianne B. surname: Dolan fullname: Dolan, Lianne B. organization: Princess Margaret Cancer Centre, Toronto, ON, Canada – sequence: 3 givenname: Larry surname: Norton fullname: Norton, Larry organization: Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 4 givenname: John B. surname: Charles fullname: Charles, John B. organization: NASA Johnson Space Center, Houston, TX, USA – sequence: 5 givenname: Lee W. surname: Jones fullname: Jones, Lee W. organization: Memorial Sloan Kettering Cancer Center, New York, NY, USA |
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| Title | Multisystem Toxicity in Cancer: Lessons from NASA’s Countermeasures Program |
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