Ganglioside Rafts as MAG Receptors That Mediate Blockade of Axon Growth

A report by Vyas et al provides evidence that gangliosides GD1a and GT1b are neuronal receptors that mediate inhibition by myelin-associated glycoprotein (MAG). MAG was the first myelin-derived growth inhibitory molecule to be reported. It is now clear that embryonic and postnatal neurons respond di...

Full description

Saved in:
Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 99; no. 12; pp. 7811 - 7813
Main Author McKerracher, Lisa
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 11.06.2002
National Acad Sciences
The National Academy of Sciences
Subjects
Animals
Axons
Axons - physiology
Cell growth
Commentaries
Gangliosides
Gangliosides - physiology
Growth cones
Membrane Microdomains - physiology
Models, Neurological
Molecules
Myelin
Myelin-Associated Glycoprotein - physiology
Nerve Regeneration - physiology
Nervous system
Neurites
Neurons
Neurons - physiology
Neuroscience
Proteins
Rafts
Rats
Receptors
Receptors, Cell Surface - physiology
Online AccessGet full text

Cover

More Information
Summary:A report by Vyas et al provides evidence that gangliosides GD1a and GT1b are neuronal receptors that mediate inhibition by myelin-associated glycoprotein (MAG). MAG was the first myelin-derived growth inhibitory molecule to be reported. It is now clear that embryonic and postnatal neurons respond differently to MAG and there is a developmental switch in the neuronal response to MAG.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Commentary-2
ObjectType-Feature-4
content type line 23
ObjectType-Review-1
ObjectType-Article-3
E-mail: mckerral@patho.umontreal.ca.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.132280299