Saying No to Drugs: Fasting Protects Hematopoietic Stem Cells from Chemotherapy and Aging

Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and prot...

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Bibliographic Details
Published inCell stem cell Vol. 14; no. 6; pp. 704 - 705
Main Authors Hine, Christopher, Mitchell, James R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 05.06.2014
Subjects
Animals
Cyclic AMP-Dependent Protein Kinases - metabolism
Fasting - physiology
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - metabolism
Immunosuppression
Insulin-Like Growth Factor I - metabolism
Regeneration
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Summary:Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic toxicity and promote rejuvenation.
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ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2014.05.016