Obesity and immunocompetence

The increasing worldwide prevalence of obesity is a major health problem since excessive body weight constitutes a risk factor in a number of chronic diseases. It has been reported that obese individuals are more susceptible to infection than lean subjects; however, the underlying factors are not fu...

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Bibliographic Details
Published inEuropean journal of clinical nutrition Vol. 56; no. S3; pp. S42 - S45
Main Authors Lamas, O, Marti, A, Martínez, JA
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.08.2002
Subjects
Adipose tissue
Adipose Tissue - metabolism
Animals
Body weight
Body weight loss
Chronic illnesses
Clinical nutrition
Complications and side effects
Dietary Fats - administration & dosage
Dietary Fats - immunology
Disease Models, Animal
Disease Susceptibility
Evaluation
Health
Heterogeneity
Humans
Immune response
Immune system
Immunity, Cellular
Immunocompetence
Immunocompetent cells
Immunology
Infection - immunology
Lymphocytes
Molecular modelling
Nutrient loss
Nutritional status
Obesity
Obesity - immunology
Obesity - physiopathology
Properties
Risk analysis
Risk factors
Rodentia
Weight control
Weight loss
Spain
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Summary:The increasing worldwide prevalence of obesity is a major health problem since excessive body weight constitutes a risk factor in a number of chronic diseases. It has been reported that obese individuals are more susceptible to infection than lean subjects; however, the underlying factors are not fully understood. Limited and often controversial information exists comparing immunocompetence in obese and nonobese subjects as well as the cellular and molecular mechanisms involved, although much evidence supports a link between adipose tissue metabolism and immunocompetent cell functions. The complexity and heterogeneity of nutritional status and immune system interactions require an integral study of the immunocompetent cells, their subsets and products, as well as specific and non-specific inducer/regulatory systems in situations of human obesity. Additional research is needed to determine the clinical implications of these alterations on immunity and whether various interventions such as weight loss, exercise or nutrient supplementation could help to ameliorate them.
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ISSN:0954-3007
1476-5640
DOI:10.1038/sj.ejcn.1601484