Polymer nanogels: A versatile nanoscopic drug delivery platform

In this review we put the spotlight on crosslinked polymer nanogels, a promising platform that has the characteristics of an “ideal” drug delivery vehicle. Some of the key aspects of drug delivery vehicle design like stability, response to biologically relevant stimuli, passive targeting, active tar...

Full description

Saved in:
Bibliographic Details
Published inAdvanced drug delivery reviews Vol. 64; no. 9; pp. 836 - 851
Main Authors Chacko, Reuben T., Ventura, Judy, Zhuang, Jiaming, Thayumanavan, S.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.06.2012
Subjects
Animals
Drug Delivery Systems - methods
Encapsulation stability
Humans
Ligand display
Nanomaterial
Polyethylene Glycols - chemistry
Polyethyleneimine - chemistry
Polymers - chemistry
Stimuli responsive
Stimuli responsive
Encapsulation stability
Ligand display
Nanomaterial
Online AccessGet full text

Cover

More Information
Summary:In this review we put the spotlight on crosslinked polymer nanogels, a promising platform that has the characteristics of an “ideal” drug delivery vehicle. Some of the key aspects of drug delivery vehicle design like stability, response to biologically relevant stimuli, passive targeting, active targeting, toxicity and ease of synthesis are discussed. We discuss several delivery systems in this light and highlight some examples of systems, which satisfy some or all of these design requirements. In particular, we point to the advantages that crosslinked polymeric systems bring to drug delivery. We review some of the synthetic methods of nanogel synthesis and conclude with the diverse applications in drug delivery where nanogels have been fruitfully employed. [Display omitted]
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2012.02.002