Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

• Published in: Revista brasileira de farmacognosia Vol. 26; no. 6; pp. 728 - 737
• Main Authors: Tauchen, Jan, Bortl, Ludvik, Huml, Lukas, Miksatkova, Petra, Doskocil, Ivo, Marsik, Petr, Villegas, Pablo Pedro Panduro, Flores, Ymber Bendezu, Damme, Patrick Van, Lojka, Bohdan, Havlik, Jaroslav, Lapcik, Oldrich, Kokoska, Ladislav
• Format: Journal Article
• Language: English; Portuguese
• Published: Cham Elsevier Editora Ltda 01.11.2016; Springer International Publishing; Sociedade Brasileira de Farmacognosia
• Subjects: Anticarcinogenic; Antioxidant; Original Article; PHARMACOLOGY & PHARMACY; Pharmacy; Phenolic compounds; Plant extracts; Anticarcinogenic; Antioxidant; Phenolic compounds; Plant extracts
• ISSN: 0102-695X; 1981-528X; 1981-528X
• DOI: 10.1016/j.bjp.2016.03.016

[Display omitted] Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC=1062.9 and 645.9±51.4μg TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29=2.7 and 9.0μg/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH=903.8 and ORAC=1024μg TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8μg/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH=337.0 and ORAC=795.7μg TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9μg/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.