Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control

• Published in: Cell Vol. 162; no. 3; pp. 488 - 492
• Main Authors: Diamond, Michael S., Pierson, Theodore C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.07.2015
• Subjects: Animals; Dengue - immunology; Dengue - prevention & control; Dengue - therapy; Dengue - virology; Dengue Vaccines - immunology; Dengue virus; Dengue Virus - immunology; Dengue Virus - physiology; disease control; Humans; Immune Evasion; pathogenesis; therapeutics; vaccines

Dengue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans each year. Here, we review recent advances in our understanding of the biology of DENV and describe knowledge gaps that have impacted the development of effective vaccines and therapeutics. Dengue vi...