Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control

Dengue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans each year. Here, we review recent advances in our understanding of the biology of DENV and describe knowledge gaps that have impacted the development of effective vaccines and therapeutics. Dengue vi...

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Bibliographic Details
Published inCell Vol. 162; no. 3; pp. 488 - 492
Main Authors Diamond, Michael S., Pierson, Theodore C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 30.07.2015
Subjects
Animals
Dengue - immunology
Dengue - prevention & control
Dengue - therapy
Dengue - virology
Dengue Vaccines - immunology
Dengue virus
Dengue Virus - immunology
Dengue Virus - physiology
disease control
Humans
Immune Evasion
pathogenesis
therapeutics
vaccines
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Summary:Dengue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans each year. Here, we review recent advances in our understanding of the biology of DENV and describe knowledge gaps that have impacted the development of effective vaccines and therapeutics. Dengue virus infects nearly 400 million humans each year. Recent insights into the disease have driven the development of vaccines and therapeutics.
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Co-corresponding authors
Michael S. Diamond, M.D., Ph.D., Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110. 314-362-2842; diamond@wusm.wustl.edu.
Theodore C. Pierson, Ph.D., National Institute of Allergy and Infectious Diseases, 33 North Drive, Room 2E19A.2, Bethesda, Maryland 20892. 301-451-7977; piersontc@mail.nih.gov.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2015.07.005