Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control
Dengue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans each year. Here, we review recent advances in our understanding of the biology of DENV and describe knowledge gaps that have impacted the development of effective vaccines and therapeutics. Dengue vi...
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| Published in | Cell Vol. 162; no. 3; pp. 488 - 492 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
30.07.2015
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Dengue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans each year. Here, we review recent advances in our understanding of the biology of DENV and describe knowledge gaps that have impacted the development of effective vaccines and therapeutics.
Dengue virus infects nearly 400 million humans each year. Recent insights into the disease have driven the development of vaccines and therapeutics. |
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| AbstractList | Dengue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans each year. Here, we review recent advances in our understanding of the biology of DENV and describe knowledge gaps that have impacted the development of effective vaccines and therapeutics. Dengue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans each year. Here, we review recent advances in our understanding of the biology of DENV and describe knowledge gaps that have impacted the development of effective vaccines and therapeutics. Dengue virus infects nearly 400 million humans each year. Recent insights into the disease have driven the development of vaccines and therapeutics. |
| Author | Pierson, Theodore C. Diamond, Michael S. |
| AuthorAffiliation | 1 Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis MO 63110 2 Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 |
| AuthorAffiliation_xml | – name: 1 Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis MO 63110 – name: 2 Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 |
| Author_xml | – sequence: 1 givenname: Michael S. surname: Diamond fullname: Diamond, Michael S. email: diamond@wusm.wustl.edu organization: Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 2 givenname: Theodore C. surname: Pierson fullname: Pierson, Theodore C. email: piersontc@mail.nih.gov organization: Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26232221$$D View this record in MEDLINE/PubMed |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 ObjectType-Feature-2 Co-corresponding authors Michael S. Diamond, M.D., Ph.D., Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110. 314-362-2842; diamond@wusm.wustl.edu. Theodore C. Pierson, Ph.D., National Institute of Allergy and Infectious Diseases, 33 North Drive, Room 2E19A.2, Bethesda, Maryland 20892. 301-451-7977; piersontc@mail.nih.gov. |
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| Snippet | Dengue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans each year. Here, we review recent advances in our... |
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| SubjectTerms | Animals Dengue - immunology Dengue - prevention & control Dengue - therapy Dengue - virology Dengue Vaccines - immunology Dengue virus Dengue Virus - immunology Dengue Virus - physiology disease control Humans Immune Evasion pathogenesis therapeutics vaccines |
| Title | Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control |
| URI | https://dx.doi.org/10.1016/j.cell.2015.07.005 https://www.ncbi.nlm.nih.gov/pubmed/26232221 https://www.proquest.com/docview/1701343056 https://www.proquest.com/docview/2000232440 https://pubmed.ncbi.nlm.nih.gov/PMC4522276 |
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