Metabolism Goes Viral

Viral and cellular oncogenes converge in targeting critical protein interaction networks to reprogram the cellular DNA and protein replication machinery for pathological replication. In this issue, Thai et al. (2014) show that adenovirus E4ORF1 activates MYC glycolytic targets to induce a Warburg-li...

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Bibliographic Details
Published inCell metabolism Vol. 19; no. 4; pp. 549 - 550
Main Authors Miyake-Stoner, Shigeki J., O’Shea, Clodagh C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2014
Subjects
Adenovirus
Adenovirus E4 Proteins - metabolism
Epithelial Cells - metabolism
Glucose - metabolism
Humans
Metabolic Networks and Pathways - physiology
Models, Biological
Proto-Oncogene Proteins c-myc - metabolism
Virus Replication - physiology
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Summary:Viral and cellular oncogenes converge in targeting critical protein interaction networks to reprogram the cellular DNA and protein replication machinery for pathological replication. In this issue, Thai et al. (2014) show that adenovirus E4ORF1 activates MYC glycolytic targets to induce a Warburg-like effect that converts glucose into nucleotides for viral replication.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Commentary-1
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ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2014.03.022