Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease

• Published in: Journal of Alzheimer's disease Vol. 33 Suppl 1; p. S253
• Main Authors: Zhu, Xiongwei, Perry, George, Smith, Mark A, Wang, Xinglong
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2013
• Subjects: Alzheimer Disease - etiology; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Animals; Brain - metabolism; Brain - pathology; Humans; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial Dynamics - physiology; Mitochondrial Proteins - metabolism; Neurons - metabolism; Neurons - pathology

Mitochondrial dysfunction is one of the most early and prominent features in vulnerable neurons in the brain of Alzheimer's disease (AD) patients. Recent studies suggest that mitochondria are highly dynamic organelles characterized by a delicate balance of fission and fusion, a concept that has...