Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease

Mitochondrial dysfunction is one of the most early and prominent features in vulnerable neurons in the brain of Alzheimer's disease (AD) patients. Recent studies suggest that mitochondria are highly dynamic organelles characterized by a delicate balance of fission and fusion, a concept that has...

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Bibliographic Details
Published inJournal of Alzheimer's disease Vol. 33 Suppl 1; p. S253
Main Authors Zhu, Xiongwei, Perry, George, Smith, Mark A, Wang, Xinglong
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2013
Subjects
Alzheimer Disease - etiology
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Animals
Brain - metabolism
Brain - pathology
Humans
Mitochondria - metabolism
Mitochondria - pathology
Mitochondrial Dynamics - physiology
Mitochondrial Proteins - metabolism
Neurons - metabolism
Neurons - pathology
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Summary:Mitochondrial dysfunction is one of the most early and prominent features in vulnerable neurons in the brain of Alzheimer's disease (AD) patients. Recent studies suggest that mitochondria are highly dynamic organelles characterized by a delicate balance of fission and fusion, a concept that has revolutionized our basic understanding of the regulation of mitochondrial structure and function which has far-reaching significance in studies of health and disease. Tremendous progress has been made in studying changes in mitochondrial dynamics in AD brain and models and the potential underlying mechanisms. This review highlights the recent work demonstrating abnormal mitochondrial dynamics and distribution in AD models and discusses how these abnormalities may contribute to various aspects of mitochondrial dysfunction and the pathogenesis of AD.
ISSN:1875-8908
DOI:10.3233/JAD-2012-129005