Fibrosis and Adipose Tissue Dysfunction

Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1α that in turn leads to a potent profibrotic transcriptional program. The pathophysiological impact of adipose tissue fibrosis is...

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Published inCell metabolism Vol. 18; no. 4; pp. 470 - 477
Main Authors Sun, Kai, Tordjman, Joan, Clément, Karine, Scherer, Philipp E.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2013
Subjects
adipose tissue
Adipose Tissue - metabolism
Cytokines - metabolism
extracellular matrix
fibrosis
Fibrosis - metabolism
Fibrosis - pathology
heart
Humans
hypoxia
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Insulin Resistance
kidneys
liver
Obesity - metabolism
Obesity - pathology
rodents
transcription (genetics)
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Summary:Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1α that in turn leads to a potent profibrotic transcriptional program. The pathophysiological impact of adipose tissue fibrosis is likely to play an equally important role on systemic metabolic alterations as fibrotic conditions play in the liver, heart, and kidney. Here, we discuss recent advances in our understanding of the genesis, modulation, and systemic impact of excessive extracellular matrix (ECM) accumulation in adipose tissue of both rodents and humans and the ensuing impact on metabolic dysfunction.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1550-4131
1932-7420
1932-7420
DOI:10.1016/j.cmet.2013.06.016