Current Approaches to the Management of Patients with Endometrial Cancer

The incidence of endometrial cancer (EC) is rising and healthcare professionals need to be informed about the latest data on the constant developments in the field of its management. With particular interest in the classification and management of EC, we surveyed current literature, national and int...

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Published inCancers Vol. 14; no. 18; p. 4500
Main Authors Kalampokas, Emmanouil, Giannis, Georgios, Kalampokas, Theodoros, Papathanasiou, Angeliki-Astero, Mitsopoulou, Dimitra, Tsironi, Evangelia, Triantafyllidou, Olga, Gurumurthy, Mahalakshmi, Parkin, David E, Cairns, Mary, Vlahos, Nikolaos F
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 16.09.2022
MDPI
Subjects
Biopsy
Cancer
Care and treatment
Cell growth
Classification
Cyclin-dependent kinases
Disease management
Endometrial cancer
Endometrium
Estrogens
Genes
Genomes
Health care
Infertility
Kinases
Lymph nodes
Lymphatic system
Medical prognosis
Metabolism
Metastasis
Mutation
Pathogenesis
Proteins
Review
Sarcoma
Surgery
Tumors
Uterus
Greece
endometrial cancer
sentinel lymph node biopsy
classification
management
lymphadenectomy
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Summary:The incidence of endometrial cancer (EC) is rising and healthcare professionals need to be informed about the latest data on the constant developments in the field of its management. With particular interest in the classification and management of EC, we surveyed current literature, national and international data, and guidelines, as well as the latest studies to present the most recent data regarding the management of EC. It became evident that despite the consensus on low-risk EC, there are still controversies surrounding the management of high-risk EC, especially regarding the role of sentinel lymph node biopsy (SLNB). Our aim is to present the old and new perspectives in the management of EC, the different available surgical routes, the possible desire for fertility preservation, the role of adjuvant therapies and the focus on the advantages and the limitations of the implementation of SLNB in therapeutic strategies. It became evident throughout our search and based on literature data that minimally invasive surgery (MIS) leads to satisfying outcomes, thus becoming gradually the preferred route of surgery, while SLNB could provide essential information and guidance about the overall management needed in cases of both low-risk and high-risk EC.
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14184500