Plasma pyridoxal 5′-phosphate and high-sensitivity C-reactive protein are independently associated with an increased risk of coronary artery disease

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 24; no. 3; pp. 239 - 244
• Main Authors: Cheng, Chien-Hsiung, M.D, Lin, Ping-Ting, Ph.D, Liaw, Yung-Po, Ph.D, Ho, Chien-Chang, M.S, Tsai, Tsung-Po, M.D., Ph.D, Chou, Ming-Chih, M.D., Ph.D, Huang, Yi-Chia, Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2008; [New York]: Elsevier Science Inc; Elsevier; Elsevier Limited
• Subjects: Aged; atherosclerosis; Biological and medical sciences; Blood pressure; C-reactive protein; C-Reactive Protein - metabolism; Cardiology. Vascular system; Cardiovascular disease; cardiovascular diseases; case studies; Case-control; Case-Control Studies; Cholesterol; Cholesterol - blood; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - epidemiology; Coronary heart disease; coronary vessels; Female; Gastroenterology and Hepatology; Heart; High-sensitivity C-reactive protein; homocysteine; Homocysteine - blood; Humans; hyperhomocysteinemia; Inflammation; Male; Medical sciences; Metabolic disorders; Middle Aged; nutritional status; Odds Ratio; patients; Plasma; Pyridoxal 5′-phosphate; pyridoxal phosphate; Pyridoxal Phosphate - blood; Pyridoxal Phosphate - deficiency; pyridoxine; Risk Factors; synergism; Vitamin B 6 - blood; Vitamin B 6 Deficiency - blood; Vitamin B 6 Deficiency - complications; Vitamin B Complex - blood; High-sensitivity C-reactive protein; Pyridoxal 5′-phosphate; Inflammation; Coronary artery disease; Case-control; Human; Biological marker; Cardiovascular disease; B-Vitamins; Pyridoxine; Case control study; Pyridoxal 5'-phosphate; Coronary heart disease; Synergism; Pyridoxal phosphate; Sensitivity; Risk factor; C reactive protein; Nutritional status
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2007.12.003

Abstract Objective Whether vitamin B6 exerts an independent or a synergic effect in combination with inflammation for the risk of coronary artery disease (CAD) is unclear. The purpose of this study was to investigate whether plasma pyridoxal 5′-phosphate (PLP) is dependent on or independent of the inflammation marker C-reactive protein (CRP) to associate with the risk of CAD. Methods This was a hospital-based case-control. Patients were identified with cardiac catheterization as having at least 70% stenosis of one major coronary artery were assigned to the case group ( n = 184). The control group ( n = 516) was comprised of healthy individuals with normal blood biochemical values. All subjects’ height, weight, blood pressure, plasma PLP, homocysteine, high-sensitivity CRP (hs-CRP), and lipid profiles were measured. Results Plasma PLP concentration was only negatively associated with hs-CRP level in the control group (β = −0.001, P = 0.03) but not in the CAD or pooled groups. The magnitude of the risk of CAD for low plasma PLP (odds ratio [OR] 2.39) and high hs-CRP (OR 3.37) was very similar. Low plasma PLP concentration combined with low hs-CRP level (OR 2.34) and high plasma PLP concentration combined with high hs-CRP level (OR 3.61) were independently associated with risk for CAD. However, the combined presence of low PLP and higher hs-CRP levels enhanced the risk of CAD and the magnitude was substantially greater (OR 4.35). Conclusion Plasma PLP and hs-CRP are independently associated with an increased risk of CAD, the combined presence of low PLP and high hs-CRP enhanced the risk of CAD, and the magnitude was almost double.