The Need for Quality Improvement in Sweat Testing Infants after Newborn Screening for Cystic Fibrosis

• Published in: The Journal of pediatrics Vol. 157; no. 6; pp. 1035 - 1037
• Main Authors: LeGrys, Vicky A., DrA, McColley, Susanna A., MD, Li, Zhanhai, PhD, Farrell, Philip M., MD, PhD
• Format: Journal Article
• Language: English
• Published: Maryland Heights, MO Mosby, Inc 01.12.2010; Elsevier
• Subjects: Biological and medical sciences; Cystic Fibrosis - diagnosis; Errors of metabolism; General aspects; Humans; Infant, Newborn; Medical sciences; Metabolic diseases; Miscellaneous hereditary metabolic disorders; Neonatal Screening - standards; Pediatrics; Prevention and actions; Prospective Studies; Public health. Hygiene; Public health. Hygiene-occupational medicine; Quality of Health Care - standards; Sweat - chemistry; CLSI; CFF; CAP; CF; Cystic Fibrosis Foundation; QNS; Newborn screening; Cystic fibrosis; Clinical and Laboratory Standards Institute; Quantity not sufficient; College of American Pathologists; NBS; Human; Pediatrics; Respiratory disease; Metabolic diseases; Infant; Medical screening; Genetic disease; Improvement; Need; Newborn; Quality; Digestive diseases; Sweat; Pancreatic disease
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2010.07.053

The proportion of insufficient sweat tests after positive newborn screening for cystic fibrosis was determined. Infants ≤3 months old had a mean (±standard deviation) rate of 7.2% (±7.6) (range, 0% to 40%). Collection methods did not affect the rates. The high and variable rates indicate a need for quality improvement.