Two cases of spindle cell variant diffuse large B-cell lymphoma of the uterine cervix

• Published in: Gynecologic oncology reports Vol. 33; p. 100611
• Main Authors: Murata, Hiroko, Nakamura, Harumi, Ohta, Yukinobu, Kitamura, Masanori, Nakastuka, Shinichi, Ishikawa, Jun, Kamiura, Shoji
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.08.2020; Elsevier
• Subjects: Case Report; Malignant lymphoma; Needle biopsy; R-CHOP chemotherapy; Spindle cell variant DLBCL; Uterine cervix; Malignant lymphoma; Uterine cervix; R-CHOP chemotherapy; Spindle cell variant DLBCL; Needle biopsy
• ISSN: 2352-5789; 2352-5789
• DOI: 10.1016/j.gore.2020.100611

•Malignant lymphoma produces a bulky and hard tumor in the uterine cervix.•Only two cases of spindle cell variant DLBCL in uterine cervix have been reported.•R-CHOP chemotherapy is very effective for DLBCL.•Accurate diagnosis is essential to avoid unnecessary surgery or medical treatment. Lymphoma with prominent spindle cell features is a morphological variant of diffuse large B-cell lymphoma (DLBCL) and is categorized as a rare variant by the WHO classification. Most cases arise from the skin, with only two cases reported in the uterine cervix to date. Here, we report two cases of spindle cell variant DLBCL of the uterine cervix. Although these cases might be rare, we believe that, as gynecologists and pathologists increase their knowledge of this variant type, more cases will be diagnosed properly.