The combination of testosterone undecanoate with tamoxifen citrate enhances the effects of each agent given independently on seminal parameters in men with idiopathic oligozoospermia

• Published in: Fertility and sterility Vol. 67; no. 4; pp. 756 - 762
• Main Authors: Adamopoulos, Dimitrios A., Nicopoulou, Stamatina, Kapolla, Niki, Karamertzanis, Maria, Andreou, Evangelia
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.04.1997; Elsevier Science
• Subjects: Acrosin - analysis; Acrosin - drug effects; Acrosin - metabolism; Adult; Aniline Compounds - analysis; Aniline Compounds - metabolism; Biological and medical sciences; Birth control; Carnitine - analysis; Carnitine - metabolism; Cohort Studies; Drug Synergism; Drug Therapy, Combination; Estrogen Antagonists - administration & dosage; Estrogen Antagonists - pharmacology; Estrogen Antagonists - therapeutic use; Gynecology. Andrology. Obstetrics; Humans; Male; Medical sciences; Middle Aged; Oligospermia - drug therapy; oligozoospermia; Prospective Studies; seminal parameters; Sperm Count - drug effects; Sperm Motility - drug effects; Sperm Motility - physiology; Spermatozoa - chemistry; Spermatozoa - drug effects; Spermatozoa - enzymology; Sterility. Assisted procreation; Tamoxifen - administration & dosage; Tamoxifen - pharmacology; Tamoxifen - therapeutic use; tamoxifen citrate; Testosterone - administration & dosage; Testosterone - analogs & derivatives; Testosterone - pharmacology; Testosterone - therapeutic use; Testosterone Congeners - administration & dosage; Testosterone Congeners - pharmacology; Testosterone Congeners - therapeutic use; Testosterone undecanoate; Time Factors; Testosterone undecanoate; tamoxifen citrate; seminal parameters; oligozoospermia; Human; Drug combination; Androgen; Semen; Antiestrogen; Idiopathic; Male; Antihormone; Semen disorders; Tamoxifene; Oligospermia; Testosterone; Chemotherapy; Treatment; Testicular hormone; Seminal plasma; Sex steroid hormone; Male genital diseases; Non steroid compound
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/S0015-0282(97)81379-9

Objective: To evaluate the effects of combined tamoxifen citrate and T undecanoate treatment on seminal parameters in men with idiopathic oligozoospermia. Design: Prospective randomized clinical study. Setting: A state hospital tertiary clinic. Patient(s): Eighty oligozoospermic men were included in the protocol. Intervention(s): Patients were randomized to receive placebo, T undecanoate (40 mg three times per day), tamoxifen citrate (10 mg two times per day), or T undecanoate plus tamoxifen citrate. Result(s): Tamoxifen citrate plus T undecanoate treatment produced a satisfactory improvement of total sperm number, motility, and functional sperm fraction after 3 and 6 months. Comparisons with other active treatment groups showed significantly higher increment values for motility and functional fraction, whereas aniline, acrosine, and free L-carnitine also were markedly better in the combination treatment group. Conclusion(s): These results indicate that the combination of tamoxifen citrate with T undecanoate not only improves significantly important seminal parameters but also compares favorably with the single treatments used. Therefore, this combination deserves a place as a first line of treatment in idiopathic oligozoospermia.