The Role of the Tumor Necrosis Factor System and Interleukin-10 during Cytomegalovirus Infection in Renal Transplant Recipients

• Published in: The Journal of infectious diseases Vol. 181; no. 1; pp. 51 - 57
• Main Authors: Nordøy, Ingvild, Müller, Fredrik, Nordal, Knut P., Rollag, Halvor, Lien, Egil, Aukrust, Pål, Frøland, Stig S.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.01.2000; University of Chicago Press; Oxford University Press
• Subjects: Adult; Aged; AIDS/HIV; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Asymptomatic diseases; Biological and medical sciences; Blood; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Cytomegalovirus; Cytomegalovirus infections; Cytomegalovirus Infections - etiology; Cytomegalovirus Infections - immunology; Female; human cytomegalovirus; Human viral diseases; Humans; Infections; Infectious diseases; Interleukin-10 - blood; Kidney Transplantation - adverse effects; Major Articles; Male; Medical sciences; Middle Aged; Miscellaneous; Monocytes; Prospective Studies; T lymphocytes; Transplantation; Tumor Necrosis Factor-alpha - analysis; Tumor necrosis factors; Viral diseases; Human; Monocyte; Herpesviridae; Cytokine; Activation; Recipient; Transplantation; Betaherpesvirinae; Kidney; Human cytomegalovirus; Infection; Virus; Urinary system; Tumor necrosis factor; Viral disease; Interleukin 10; T-Lymphocyte; Complication
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/315184

The effects of cytomegalovirus (CMV) infection on monocyte and T cell activation and the role of the tumor necrosis factor (TNF) system and interleukin (IL)-10 were studied in a prospective study of 25 renal transplant recipients. Ten patients developed CMV disease (group A), 5 developed asymptomatic infection (group B), and 10 did not have CMV infection (group C). During CMV disease (group A), there was evidence of both monocyte and T cell activation. All patients with CMV infection (groups A and B) showed increased activation of the TNF system, concomitant with an increase in plasma levels of IL-10. Patients with CMV disease (group A) had more marked manifestations of TNF activation and more moderate IL-10 increase than patients with asymptomatic CMV infection (group B), reflected in a higher plasma IL-10/TNF-α ratio in asymptomatic patients. Thus, the balance between TNF-α and IL-10 may be important in the development of CMV infection and CMV-related disease.