Relapsing Aspergillus otomycosis despite prolonged systemic antifungal therapy and resolution after topical voriconazole administration: A case report

We report a case of intractable Aspergillus otomycosis with multiple relapses despite conventional topical and systemic antifungal treatment, and adjunctive usage of hyperbaric oxygen therapy. Of note, otomycosis relapsed even after six months of continuous systemic antifungal treatment with therape...

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Bibliographic Details
Published inMedical mycology case reports Vol. 39; pp. 23 - 25
Main Authors Wee, Liang En, Tan, Mei Gie, Tan, Ai Ling, Tang, Joyce Zhi-en
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2023
Elsevier
Subjects
Aspergillus
Case Report
Isavuconazole
Otitis externa
Otomycosis
Voriconazole
Aspergillus
Otomycosis
Isavuconazole
Otitis externa
Voriconazole
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Summary:We report a case of intractable Aspergillus otomycosis with multiple relapses despite conventional topical and systemic antifungal treatment, and adjunctive usage of hyperbaric oxygen therapy. Of note, otomycosis relapsed even after six months of continuous systemic antifungal treatment with therapeutic drug levels and without treatment interruption; and only resolved after application of topical voriconazole. (max. 75 words)
ISSN:2211-7539
2211-7539
DOI:10.1016/j.mmcr.2022.12.006