Expression of the IL-10 receptor on human monocytes is moderately suppressed by glucocorticoids

• Published in: International immunopharmacology Vol. 2; no. 10; pp. 1491 - 1493
• Main Authors: Visser, Jeroen, Nagelkerken, Lex
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.09.2002; Elsevier
• Subjects: Biological and medical sciences; Dexamethasone - pharmacology; Glucocorticoids; Humans; IL-10 receptor; Immunomodulators; Medical sciences; Monocytes; Monocytes - chemistry; Monocytes - drug effects; Pharmacology. Drug treatments; Receptors, Interleukin - analysis; Receptors, Interleukin-10; Glucocorticoids; IL-10 receptor; Monocytes; Human; Corticosteroid; Cell culture; Dexamethasone; Monocyte; Steroid hormone; Immunomodulation; Antiinflammatory agent; Cytokine; Gene expression; Glucocorticoid; In vitro; Biological activity; Immunosuppression; Interleukin 10; Th2 lymphocyte; Mechanism of action; Biological receptor
• ISSN: 1567-5769; 1878-1705
• DOI: 10.1016/S1567-5769(02)00113-3

The anti-inflammatory cytokine IL-10 has also been demonstrated to generate Th2-inducing antigen-presenting cells (APC). For instance, dendritic cells (DC) treated with IL-10 downregulate their production of IL-12 and the expression of co-stimulatory molecules. These DC become tolerogenic and favour the induction of a Th2 response. In order to know if IL-10 and glucocorticoids (GC) can work in concert to suppress inflammatory immune responses, it has to be investigated whether pharmacological concentrations of GC strongly downregulate the expression of the IL-10 receptor on APC. For this purpose, we investigated the effect of 1 mu M dexamethasone on the IL-10 receptor expression on human monocytes.