Reservoir-based drug delivery systems utilizing microtechnology

• Published in: Advanced drug delivery reviews Vol. 64; no. 14; pp. 1590 - 1602
• Main Authors: Stevenson, Cynthia L., Santini, John T., Langer, Robert
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2012
• Subjects: Administration, Cutaneous; Administration, Oral; Controlled release; Drug Delivery Systems; Drug Implants; Equipment Design; Humans; Implant; MEMS; Microneedle; Micropump; Microtechnology - instrumentation; Microtechnology - methods; Ocular; On demand; Pharmaceutical Preparations - administration & dosage; Pulsatile; On demand; Implant; Ocular; Pulsatile; MEMS; Controlled release; Microneedle; Micropump

This review covers reservoir-based drug delivery systems that incorporate microtechnology, with an emphasis on oral, dermal, and implantable systems. Key features of each technology are highlighted such as working principles, fabrication methods, dimensional constraints, and performance criteria. Re...