Reservoir-based drug delivery systems utilizing microtechnology

• Published in: Advanced drug delivery reviews Vol. 64; no. 14; pp. 1590 - 1602
• Main Authors: Stevenson, Cynthia L., Santini, John T., Langer, Robert
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2012
• Subjects: Administration, Cutaneous; Administration, Oral; Controlled release; Drug Delivery Systems; Drug Implants; Equipment Design; Humans; Implant; MEMS; Microneedle; Micropump; Microtechnology - instrumentation; Microtechnology - methods; Ocular; On demand; Pharmaceutical Preparations - administration & dosage; Pulsatile; On demand; Implant; Ocular; Pulsatile; MEMS; Controlled release; Microneedle; Micropump
• ISSN: 0169-409X; 1872-8294
• DOI: 10.1016/j.addr.2012.02.005

This review covers reservoir-based drug delivery systems that incorporate microtechnology, with an emphasis on oral, dermal, and implantable systems. Key features of each technology are highlighted such as working principles, fabrication methods, dimensional constraints, and performance criteria. Reservoir-based systems include a subset of microfabricated drug delivery systems and provide unique advantages. Reservoirs, whether external to the body or implanted, provide a well-controlled environment for a drug formulation, allowing increased drug stability and prolonged delivery times. Reservoir systems have the flexibility to accommodate various delivery schemes, including zero order, pulsatile, and on demand dosing, as opposed to a standard sustained release profile. Furthermore, the development of reservoir-based systems for targeted delivery for difficult to treat applications (e.g., ocular) has resulted in potential platforms for patient therapy. [Display omitted]