Paraneoplastic remitting seronegative symmetrical synovitis with pitting edema (RS3PE), improved following surgical resection of prostatic carcinoma: A case report

• Published in: Urology case reports Vol. 32; p. 101232
• Main Authors: Yajima, Shugo, Ooeda, Tooru, Inoue, Masaharu, Suzuki, Hiroaki, Matsumoto, Shunya, Masuda, Hitoshi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2020; Elsevier
• Subjects: Corticosteroids; Oncology; Paraneoplastic syndrome; Prostate cancer; RS3PE; CRP; Corticosteroids; Anti-CCP; RS3PE; Tumor necrosis factor a; Interleukin 6; Rheumatoid factor; ANA; MMP-3; Remitting seronegative symmetrical synovitis with pitting edema; Paraneoplastic syndrome; Prostate cancer; PSA; Rheumatoid factor, (RF); Interleukin 6, (IL-6); PSA, (Prostate-specific antigen); Tumor necrosis factor a, (TNF-a); ANA, (antinuclear antibody); Remitting seronegative symmetrical synovitis with pitting edema, (RS3PE); CRP, (C reactive protein); MMP-3, Matrix metalloproteinase-3; Anti-CCP, (Anti-cyclic citrullinated peptide)
• ISSN: 2214-4420; 2214-4420
• DOI: 10.1016/j.eucr.2020.101232

RS3PE syndrome is a rare condition that occurs in elderly individuals which can present alone or in association with various rheumatic or malignant diseases. We present a case of a 77-year-old man who was diagnosed with adenocarcinoma of the prostate and initially under active surveillance. 2 months after the diagnosis, he presented with arthralgia in both shoulders and knees, pitting edema of the both hands and feet. The patient underwent radical prostatectomy since the link between prostatic carcinoma and RS3PE was suspected. After 7 months from operation, the patient has no symptoms or signs of RS3PE. •Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a rare clinical condition which is characterized by acute onset symmetrical distal synovitis, pitting edema of the dorsum of the hands, and seronegativity of rheumatoid factor (RF).•RS3PE syndrome can present alone or in association with various rheumatic or malignant diseases.•We reported the case of RS3PE syndrome improved following surgical resection of prostatic carcinoma.•Patients diagnosed with RS3PE syndrome should be carefully investigated for a possible neoplasm.