Non-Coding RNAs of Extracellular Vesicles: Key Players in Organ-Specific Metastasis and Clinical Implications

Extracellular vesicles (EVs) are heterogeneous membrane-encapsulated vesicles released by most cells. They act as multifunctional regulators of intercellular communication by delivering bioactive molecules, including non-coding RNAs (ncRNAs). Metastasis is a major cause of cancer-related death. Most...

Full description

Saved in:
Bibliographic Details
Published inCancers Vol. 14; no. 22; p. 5693
Main Authors Jiang, Qian, Tan, Xiao-Ping, Zhang, Cai-Hua, Li, Zhi-Yuan, Li, Du, Xu, Yan, Liu, Yu Xuan, Wang, Lingzhi, Ma, Zhaowu
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 19.11.2022
MDPI
Subjects
Angiogenesis
Biomarkers
Biosynthesis
Bone marrow
Cancer
Cell death
Cell interactions
Cell organelles
Communication
Development and progression
Extracellular vesicles
Gene expression
Genetic aspects
Health aspects
Liver
Lymph nodes
Membrane vesicles
Metastases
Metastasis
Non-coding RNA
Organotropism
Patients
Phenotypes
Prostate
Proteins
Review
RNA
Therapeutic applications
Therapeutic targets
Tumor cells
Tumors
China
organ-specific metastasis
anti-cancer metastasis
extracellular vesicles
cancer biomarkers
noncoding RNAs
Online AccessGet full text

Cover

More Information
Summary:Extracellular vesicles (EVs) are heterogeneous membrane-encapsulated vesicles released by most cells. They act as multifunctional regulators of intercellular communication by delivering bioactive molecules, including non-coding RNAs (ncRNAs). Metastasis is a major cause of cancer-related death. Most cancer cells disseminate and colonize a specific target organ via EVs, a process known as "organ-specific metastasis". Mounting evidence has shown that EVs are enriched with ncRNAs, and various EV-ncRNAs derived from tumor cells influence organ-specific metastasis via different mechanisms. Due to the tissue-specific expression of EV-ncRNAs, they could be used as potential biomarkers and therapeutic targets for the treatment of tumor metastasis in various types of cancer. In this review, we have discussed the underlying mechanisms of EV-delivered ncRNAs in the most common organ-specific metastases of liver, bone, lung, brain, and lymph nodes. Moreover, we summarize the potential clinical applications of EV-ncRNAs in organ-specific metastasis to fill the gap between benches and bedsides.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
These authors contributed equally to this work.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14225693