Normal Pubertal Development in Daughters of Women with PCOS: A Controlled Study

• Published in: The journal of clinical endocrinology and metabolism Vol. 102; no. 1; pp. 122 - 131
• Main Authors: Legro, Richard S, Kunselman, Allen R, Stetter, Christy M, Gnatuk, Carol L, Estes, Stephanie J, Brindle, Eleanor, Vesper, Hubert W, Botelho, Julianne C, Lee, Peter A, Dodson, William C
• Format: Journal Article
• Language: English
• Published: Washington, DC Endocrine Society 01.01.2017; Oxford University Press
• Subjects: Androgens; Biomarkers - analysis; Body Composition; Body mass; Bone mass; Case-Control Studies; Child; Child of Impaired Parents - statistics & numerical data; Clinical s; Dehydroepiandrosterone; Dehydroepiandrosterone sulfate; Dual energy X-ray absorptiometry; Female; Follow-Up Studies; Glucose; Glucose Tolerance Test; Gonadotropins; Health care facilities; Hirsutism; Humans; Insulin; Insulin - metabolism; Lean body mass; Luteinizing hormone; Male; Metabolism; Nuclear Family; Ontogeny; Pituitary (anterior); Polycystic ovary syndrome; Polycystic Ovary Syndrome - physiopathology; Prognosis; Puberty; Puberty - metabolism; Sex hormones; Sexual Maturation - physiology; Steroids; Sulfates; Testosterone; Testosterone - blood
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2016-2707

CONTEXT:Daughters of women with polycystic ovary syndrome (PCOS) are thought to be at increased risk for developing stigmata of the syndrome, but the ontogeny during puberty is uncertain.OBJECTIVE:To phenotype daughters (N = 76) of mothers with PCOS and daughters (N = 80) from control mothers for reproductive and metabolic parameters characteristic of PCOS.DESIGN, SETTING, AND PARTICIPANTS:Matched Case/Control Study, Penn State Hershey Medical Center, Non-Hispanic, Caucasian girls age 4-17INTERVENTION:Obtain birth history, biometric, ovarian ultrasounds, whole body DXA scan for body composition, 2 hour glucose challenged salivary insulin levels and two timed urinary collections (12 hours overnight and 3 hours AM) for gonadotropins and sex steroids.MAIN OUTCOME MEASURES:Main Endpoints: Integrated urinary levels of adrenal (DHEAS) and ovarian (Testosterone) steroids. Other endpoints: Integrated salivary insulin levels and urinary LH levels.RESULTS:There were no differences in detection rates or mean levels for gonadotropins and sex steroids in timed urinary collections between PCOS Daughters and Control Daughters, nor were there differences in integrated salivary insulin levels. 69% of Tanner 4/5 PCOS daughters vs. 31% of control daughters had hirsutism defined as a Ferriman-Gallwey score > 8 (P=0.04). There were no differences in body composition as determined by DXA between groups in the three major body contents, i.e. bone, lean body mass and fat, or in in ovarian volume between groups.CONCLUSIONS:Matched for pubertal stage, PCOS daughters have similar levels of urinary androgens and gonadotropins as well as glucose challenged salivary insulin levels.