Purinergic transmission in the rostral but not caudal medullary raphe contributes to the hypercapnia-induced ventilatory response in unanesthetized rats

• Published in: Respiratory physiology & neurobiology Vol. 184; no. 1; pp. 41 - 47
• Main Authors: da Silva, Glauber S.F, Moraes, Davi J.A, Giusti, Humberto, Dias, Mirela Barros, Glass, Mogens L
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.10.2012
• Subjects: Animals; ATP; Brain; Carbon dioxide; Central chemoreception; Central nervous system; Chemoreceptors (internal); Consciousness; Data processing; Hypercapnia; Hypercapnia - metabolism; Hypercapnia - physiopathology; Male; Medical Education; Medullary raphe; Microinjection; Microinjections; Nervous system; Neurotransmission; P2X receptor; pH effects; Platelet Aggregation Inhibitors - administration & dosage; Pulmonary Ventilation - physiology; Pulmonary/Respiratory; Purine P2 receptors; Purine P2X receptors; Purines - metabolism; Pyridoxal Phosphate - administration & dosage; Pyridoxal Phosphate - analogs & derivatives; Raphe Nuclei - drug effects; Raphe Nuclei - metabolism; Raphe Nuclei - physiopathology; Rats; Rats, Wistar; Receptors, Purinergic P2X - metabolism; Respiration; Synaptic Transmission - drug effects; Synaptic Transmission - physiology; Ventilation; Hypercapnia; Central chemoreception; P2X receptor; ATP; Medullary raphe
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2012.07.015

Highlights ► The medullary raphe (MR) is an important site for central chemoreception. ► ATP signalling has been implicated in CO2 /pH sensitivity. ► We have examined the role of P2X receptors in the MR on CO2 respiratory responses. ► PPADS into the rostral, but not caudal MR, decreased the ventilatory response to CO2 . ► P2X receptors in the rostral MR play an excitatory role in hypercapnic chemoreflex.