Serum and glucocorticoid kinase 1 promoted the growth and migration of non-small cell lung cancer cells

Serum and glucocorticoid kinase 1 (SGK1) has been reported to be up-regulated in non-small cell lung cancer (NSCLC). However, its functions in NSCLC remained unclear. Here, SGK1 was found to be up-regulated in NSCLC samples. Over-expression of SGK1 promoted the growth and migration of NSCLC cells, w...

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Published inGene Vol. 576; no. 1; pp. 339 - 346
Main Authors Xiaobo, Yu, Qiang, Lin, Xiong, Qin, Zheng, Ruan, Jianhua, Zhou, Zhifeng, Lin, Yijiang, Su, Zheng, Jian
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.01.2016
Subjects
Animals
Base Sequence
beta Catenin - genetics
beta Catenin - metabolism
Beta-catenin/TCF signaling
blood serum
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - pathology
Cell growth and migration
Cell Line, Tumor
Cell Movement - genetics
Cell Proliferation - genetics
gene expression regulation
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
genes
growth retardation
Humans
Immediate-Early Proteins - genetics
Immediate-Early Proteins - metabolism
lung neoplasms
Lung Neoplasms - genetics
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
metastasis
Mice, Nude
Molecular Sequence Data
neoplasm cells
NSCLC
phosphorylation
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - metabolism
SGK1
Signal Transduction
TCF Transcription Factors - metabolism
transcription (genetics)
Xenograft Model Antitumor Assays
GFP
PBS
NSCLC
PI3K
FBS
Beta-catenin/TCF signaling
SGK1
ATCC
Cell growth and migration
Online AccessGet full text

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Abstract Serum and glucocorticoid kinase 1 (SGK1) has been reported to be up-regulated in non-small cell lung cancer (NSCLC). However, its functions in NSCLC remained unclear. Here, SGK1 was found to be up-regulated in NSCLC samples. Over-expression of SGK1 promoted the growth and migration of NSCLC cells, while down-regulation of SGK1 inhibited the growth, migration and metastasis of NSCLC cells. SGK1 promoted the phosphorylation of GSK3 beta and the accumulation of beta-catenin, up-regulation of the target genes downstream of beta-catenin/TCF signaling, and activating the transcriptional activity of beta-catenin/TCF complex. Collectively, SGK1 might promote the progression of NSCLC through activating beta-catenin/TCF signaling. •SGK1 is overexpressed in NSCLC samples.•SGK1 positively regulates the growth, migration and metastasis of NSCLC cells.•SGK1 activates beta-catenin/TCF signaling in NSCLC cells.
AbstractList Serum and glucocorticoid kinase 1 (SGK1) has been reported to be up-regulated in non-small cell lung cancer (NSCLC). However, its functions in NSCLC remained unclear. Here, SGK1 was found to be up-regulated in NSCLC samples. Over-expression of SGK1 promoted the growth and migration of NSCLC cells, while down-regulation of SGK1 inhibited the growth, migration and metastasis of NSCLC cells. SGK1 promoted the phosphorylation of GSK3 beta and the accumulation of beta-catenin, up-regulation of the target genes downstream of beta-catenin/TCF signaling, and activating the transcriptional activity of beta-catenin/TCF complex. Collectively, SGK1 might promote the progression of NSCLC through activating beta-catenin/TCF signaling.
Serum and glucocorticoid kinase 1 (SGK1) has been reported to be up-regulated in non-small cell lung cancer (NSCLC). However, its functions in NSCLC remained unclear. Here, SGK1 was found to be up-regulated in NSCLC samples. Over-expression of SGK1 promoted the growth and migration of NSCLC cells, while down-regulation of SGK1 inhibited the growth, migration and metastasis of NSCLC cells. SGK1 promoted the phosphorylation of GSK3 beta and the accumulation of beta-catenin, up-regulation of the target genes downstream of beta-catenin/TCF signaling, and activating the transcriptional activity of beta-catenin/TCF complex. Collectively, SGK1 might promote the progression of NSCLC through activating beta-catenin/TCF signaling. •SGK1 is overexpressed in NSCLC samples.•SGK1 positively regulates the growth, migration and metastasis of NSCLC cells.•SGK1 activates beta-catenin/TCF signaling in NSCLC cells.
Author Xiong, Qin
Yijiang, Su
Qiang, Lin
Jianhua, Zhou
Zhifeng, Lin
Zheng, Ruan
Zheng, Jian
Xiaobo, Yu
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Keywords GFP
PBS
NSCLC
PI3K
FBS
Beta-catenin/TCF signaling
SGK1
ATCC
Cell growth and migration
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Snippet Serum and glucocorticoid kinase 1 (SGK1) has been reported to be up-regulated in non-small cell lung cancer (NSCLC). However, its functions in NSCLC remained...
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StartPage 339
SubjectTerms Animals
Base Sequence
beta Catenin - genetics
beta Catenin - metabolism
Beta-catenin/TCF signaling
blood serum
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - pathology
Cell growth and migration
Cell Line, Tumor
Cell Movement - genetics
Cell Proliferation - genetics
gene expression regulation
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
genes
growth retardation
Humans
Immediate-Early Proteins - genetics
Immediate-Early Proteins - metabolism
lung neoplasms
Lung Neoplasms - genetics
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
metastasis
Mice, Nude
Molecular Sequence Data
neoplasm cells
NSCLC
phosphorylation
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - metabolism
SGK1
Signal Transduction
TCF Transcription Factors - metabolism
transcription (genetics)
Xenograft Model Antitumor Assays
Title Serum and glucocorticoid kinase 1 promoted the growth and migration of non-small cell lung cancer cells
URI https://dx.doi.org/10.1016/j.gene.2015.10.072
https://www.ncbi.nlm.nih.gov/pubmed/26548813
https://www.proquest.com/docview/1749991605
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