Long-term phosphorus restriction prevents corticomedullary nephrocalcinosis and sustains reproductive performance but delays bone mineralization in rats

• Published in: The Journal of nutrition Vol. 123; no. 4; pp. 754 - 763
• Main Authors: Ritskes-Hoitinga, J, Mathot, J.N.J.J, Lemmens, A.G, Danse, L.H.J.C, Meijer, G.W, Tintelen, G. van, Beynen, A.C
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Nutritional Sciences 01.04.1993
• Subjects: Administration, Oral; Afdeling Humane voeding; Animals; Biological and medical sciences; Body Weight - drug effects; Calcification, Physiologic - drug effects; CARENCE MINERALE; CONTROL DE ENFERMEDADES; CONTROLE DE MALADIES; DEFICIENCIA DE MINERALES; DIETA; Diseases of the urinary system; Dose-Response Relationship, Drug; ENFERMEDADES RENALES; EXPERIMENTACION; EXPERIMENTATION; Female; FORMACION OSEA; FORMATION DES OS; FOSFORO; Human Nutrition; Human Nutrition & Health; Human Nutrition (HNE); Humane Voeding; Humane Voeding & Gezondheid; Male; Medical sciences; MINERALES; MINERAUX; Nephrocalcinosis - prevention & control; NEPHROPATHIE; PERFORMANCE DE REPRODUCTION; PHOSPHORE; Phosphorus - deficiency; Phosphorus - pharmacology; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); RAT; RATA; Rats; Rats, Wistar; REGIME ALIMENTAIRE; Reproduction - drug effects; REPRODUCTIVIDAD; Space life sciences; Nephrocalcinosis; Urinary system disease; Nutrition; Rat; Growth; Pathogenesis; Rodentia; Renal disease; Phosphorus; Long term; Feeding; Urinary stone; Prevention; Vertebrata; Mammalia; Diet therapy; Follow up study; Mineralization; Animal; Development; Female; Bone; Restricted diet; Reproductive potential
• ISSN: 0022-3166; 1541-6100
• DOI: 10.1093/jn/123.4.754

In a long-term experiment with three successive generations of rats, the influence of dietary phosphorus restriction (2 instead of 4 g phosphorus/kg diet) on nephrocalcinosis, reproduction and bone mineralization was studied. Nephrocalcinosis in female rats, as based on kidney calcium concentration and histological examination, was prevented by phosphorus restriction. The low phosphorus diet caused reduced femur concentrations of magnesium, calcium and phosphorus in rats of the first and second generation aged 4 to 12 wk. The low phosphorus diet resulted in lower plasma phosphorus concentrations. In the kidneys of female rats, immediately after lactation, a higher degree of tubular hyperplasia was seen after the low phosphorus diet was fed. Reproductive performance was not affected by phosphorus restriction. We conclude that 0.2% phosphorus in the diet prevents nephrocalcinosis in female rats while it sustains reproduction but delays bone mineralization