Successful treatment of rhino-cerebral mucormycosis with dual antifungal therapy and minimal surgical debridement

The authors report the case of a 42-year-old female with history of type I diabetes mellitus and recent episode of diabetic ketoacidosis who presented with symptoms of epistaxis, gastrointestinal upset, hyperglycemia, confusion, and a cough. She was found to have rhino-cerebral mucormycosis with ass...

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Published inIDCases Vol. 30; p. e01615
Main Authors Bougioukas, Lauren, Noyes, Cindy D., Peterson, Katherine, Smith, Lindsay M., Hale, Andrew J.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.01.2022
Elsevier
Subjects
Amphotericin B
Case Report
Intracerebral
Invasive fungal infection
Isavuconazole
Liposomal amphotericin B
Mucormycosis
Rhino-cerebral mucormycosis
Mucormycosis
Liposomal amphotericin B
Amphotericin B
Rhino-cerebral mucormycosis
Invasive fungal infection
Intracerebral
Isavuconazole
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Summary:The authors report the case of a 42-year-old female with history of type I diabetes mellitus and recent episode of diabetic ketoacidosis who presented with symptoms of epistaxis, gastrointestinal upset, hyperglycemia, confusion, and a cough. She was found to have rhino-cerebral mucormycosis with associated multi-focal strokes and a left internal carotid artery pseudoaneurysm. Her infection was successfully treated with dual-antifungal therapy consisting of liposomal amphotericin B and isavuconazole, and required only minimal surgical debridement.
ISSN:2214-2509
2214-2509
DOI:10.1016/j.idcr.2022.e01615